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p53 modulation of the DNA damage response
Author(s) -
Helton E. Scott,
Chen Xinbin
Publication year - 2006
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21091
Subject(s) - dna damage , dna repair , microbiology and biotechnology , suppressor , cell cycle checkpoint , biology , dna , cell cycle , cell , cell fate determination , cell growth , cancer research , genetics , transcription factor , gene
The tumor suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell survival by inducing cell cycle arrest, DNA repair, and other pro‐survival pathways. However, when cells accumulate DNA damage or demonstrate aberrant growth, p53 can direct the elimination of damaged cells. In this review, we will discuss the transcriptional‐dependent and ‐independent roles of p53 in regulating the DNA damage response. J. Cell. Biochem. 100: 883–896, 2007. © 2006 Wiley‐Liss, Inc.