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Radiation‐induced bystander effect: Activation of signaling molecules in K562 erythroleukemia cells
Author(s) -
Mitra Anirban Kumar,
Krishna Malini
Publication year - 2006
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21084
Subject(s) - bystander effect , k562 cells , microbiology and biotechnology , chemistry , cancer research , biology , cell , immunology , biochemistry
Gap junction independent signaling mechanism was investigated using K562 human erythroleukemia cells. They were exposed to 2, 5, or 10 Gy of 60 Co γ irradiation, the medium isolated 20 min post‐irradiation and added to fresh cells. Evidence of radiation‐induced bystander effect was observed wherein there was activation of p21, nuclear factor‐κB (NF‐κB), Bax, Bcl‐2 and cleavage of poly(ADP‐ribose) polymerase in bystander cells. The study implicates the involvement of signaling molecules released into the medium and factors like stable free radicals that are generated in the surrounding medium. The response elicited appears to be primarily via NF‐κB and p21 activation. J. Cell. Biochem. 100: 991–997, 2007. © 2006 Wiley‐Liss, Inc.