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Centrosome function in normal and tumor cells
Author(s) -
Sankaran Satish,
Parvin Jeffrey D.
Publication year - 2006
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21003
Subject(s) - centrosome , mitosis , centrosome cycle , biology , microbiology and biotechnology , plk1 , spindle apparatus , cell division , spindle pole body , function (biology) , cell , genetics , cell cycle
Centrosomes nucleate microtubules that form the mitotic spindle and regulate the equal division of chromosomes during cell division. In cancer, centrosomes are often found amplified to greater than two per cell, and these tumor cells frequently have aneuploid genomes. In this review, we will discuss the cellular factors that regulate the proper duplication of the centrosome and how these regulatory steps can lead to abnormal centrosome numbers and abnormal mitoses. In particular, we highlight the newly emerging role of the Breast Cancer 1 (BRCA1) ubiquitin ligase in this process. J. Cell. Biochem. 99: 1240–1250, 2006. © 2006 Wiley‐Liss, Inc.