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The impact of cell adhesion changes on proliferation and survival during prostate cancer development and progression
Author(s) -
Knudsen Beatrice S.,
Miranti Cindy K.
Publication year - 2006
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20934
Subject(s) - prostate cancer , integrin , cell adhesion , cancer research , metastasis , epithelium , prostate , cell growth , androgen receptor , biology , cancer cell , basement membrane , cancer , cell , pathology , microbiology and biotechnology , medicine , biochemistry
In the normal prostate epithelium, androgen receptor (AR) negative basal epithelial cells adhere to the substratum, while AR expressing secretory cells lose substratum adhesion. In contrast, prostate cancer cells both express AR and adhere to a tumor basement membrane. In this review, we describe the differential expression of integrins, growth factor receptors (GFRs), and AR in normal and cancerous epithelium. In addition, we discuss how signals from integrins, GFRs, and AR are integrated to regulate the proliferation and survival of normal and malignant prostate epithelial cells. While cell adhesion is likely of great importance when considering therapeutic approaches for treatment of metastatic prostate cancer, no data on integrin expression are available from tissues of prostate cancer metastasis. However, several drug targets that are upregulated after androgen ablative therapy regulate cell adhesion and thus novel targeted therapies indirectly interfere with cell adhesion mechanisms in prostate cancer cells. J. Cell. Biochem. 99: 345–361, 2006. © 2006 Wiley‐Liss, Inc.