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Photodynamic cell‐kill analysis of breast tumor cells with a tamoxifen‐pyropheophorbide conjugate
Author(s) -
Gacio Ana Fernandez,
FernandezMarcos Carlos,
Swamy Narasimha,
Dunn Darra,
Ray Rahul
Publication year - 2006
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20932
Subject(s) - tamoxifen , antiestrogen , photodynamic therapy , cancer research , estrogen receptor , breast cancer , conjugate , cell , selective estrogen receptor modulator , cancer cell , estrogen , cancer , chemistry , medicine , biochemistry , mathematical analysis , mathematics , organic chemistry
We hypothesized that estrogen receptor (ER) in hormone‐sensitive breast cancer cells could be targeted for selective photodynamic killing of tumor cell with antiestrogen‐porphyrin conjugates by combining the over‐expression of ER in hormone‐sensitive breast cancer cells and tumor‐retention property of porphyrin photosensitizers. In this study we describe that a tamoxifen (TAM)‐pyropheophorbide conjugate that specifically binds to ERα, caused selective cell‐kill in MCF‐7 breast cancer cells upon light exposure. Therefore, it is a potential candidate for ER‐targeted photodynamic therapy of cancers (PDT) of tissues and organs that respond to estrogens/antiestrogens. J. Cell. Biochem. 99: 665–670, 2006. © 2006 Wiley‐Liss, Inc.