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CK2 signaling in androgen‐dependent and ‐independent prostate cancer
Author(s) -
Wang Guixia,
Ahmad Kashif A.,
Unger Gretchen,
Slaton Joel W.,
Ahmed Khalil
Publication year - 2006
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20847
Subject(s) - prostate cancer , androgen , androgen receptor , cancer research , prostate , cancer , medicine , oncology , biology , endocrinology , hormone
Protein serine/threonine kinase casein kinase 2 (CK2) is a key player in cell growth and proliferation but is also a potent suppressor of apoptosis. CK2 has been found to be dysregulated in all the cancers that have been examined, including prostate cancer. Investigations of CK2 signaling in the prostate were originally initiated in this laboratory, and these studies have identified significant functional activities of CK2 in relation to normal prostate growth and to the pathobiology of androgen‐dependent and ‐independent prostate cancer. We present a brief overview of these developments in the context of prostate biology. An important outcome of these studies is the emerging concept that CK2 can be effectively targeted for cancer therapy. J. Cell. Biochem. 99: 382–391, 2006. © 2006 Wiley‐Liss, Inc.