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Playing with bone and fat
Author(s) -
Gimble Jeffrey M.,
Zvonic Sanjin,
Floyd Z. Elizabeth,
Kassem Moustapha,
Nuttall Mark E.
Publication year - 2006
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20777
Subject(s) - mesenchymal stem cell , bone marrow , stromal cell , osteoblast , lineage (genetic) , osteoporosis , bone formation , in vivo , microbiology and biotechnology , in vitro , biology , medicine , cancer research , immunology , endocrinology , genetics , gene
The relationship between bone and fat formation within the bone marrow microenvironment is complex and remains an area of active investigation. Classical in vitro and in vivo studies strongly support an inverse relationship between the commitment of bone marrow‐derived mesenchymal stem cells or stromal cells to the adipoctye and osteoblast lineage pathways. In this review, we focus on the recent literature exploring the mechanisms underlying these differentiation events and discuss their implications relevant to osteoporosis and regenerative medicine. J. Cell. Biochem. 98: 251–266, 2006. © 2006 Wiley‐Liss, Inc.