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DNA vaccines: Successes and limitations in cancer and infectious disease
Author(s) -
Lowe Devin B.,
Shearer Michael H.,
Kennedy Ronald C.
Publication year - 2006
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20775
Subject(s) - dna vaccination , vaccination , infectious disease (medical specialty) , disease , immune system , cancer , immunology , dna , plasmid , medicine , biology , virology , immunization , genetics
Vaccination with plasmid DNA is an active area of investigation that is being applied to diseases including cancer and microbial pathogens associated with infectious diseases. Since its discovery, great progress has been made with the administration of DNA vaccines to initiate specific and effective immune responses against targeted illnesses. However, many obstacles still face its use in prophylactic and therapeutic vaccination scenarios. The nature of these difficulties alongside the successes and future of plasmid DNA will be discussed. J. Cell. Biochem. 98: 235–242, 2006. © 2006 Wiley‐Liss, Inc.