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The significance of telomeric aggregates in the interphase nuclei of tumor cells
Author(s) -
Mai Sabine,
Garini Yuval
Publication year - 2006
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20760
Subject(s) - telomere , genome instability , shelterin , interphase , carcinogenesis , biology , genetics , chromosome instability , chromosome , genome , gene , cell cycle , cancer , microbiology and biotechnology , dna , dna damage , dna binding protein , transcription factor
Telomeres are TTAGGG repetitive motifs found at the ends of vertebrate chromosomes. In humans, telomeres are protected by shelterin, a complex of six proteins (de Lange [2005] Genes Dev. 19: 2100–2110). Since (Müller [1938] Collecting Net. 13: 181–198; McClintock [1941] Genetics 26: 234–282), their function in maintaining chromosome stability has been intensively studied. This interest, especially in cancer biology, stems from the fact that telomere dysfunction is linked to genomic instability and tumorigenesis (Gisselsson et al. [2001] Proc. Natl. Acad. Sci. USA 98: 12683–12688; Deng et al. [2003] Genes Chromosomes Cancer 37: 92–97; DePinho and Polyak [2004] Nat. Genetics 36: 932–934; Meeker et al. [2004] Clin. Cancer Res. 10: 3317–3326). In the present overview, we will discuss the role of telomeres in genome stability, recent findings on three‐dimensional (3D) changes of telomeres in tumor interphase nuclei, and outline future avenues of research. J. Cell. Biochem. 97: 904–915, 2006. © 2006 Wiley‐Liss, Inc.