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Regulating leukotriene synthesis: The role of nuclear 5‐lipoxygenase
Author(s) -
Brock Thomas G.
Publication year - 2005
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20662
Subject(s) - lipoxygenase , leukotriene , arachidonate 5 lipoxygenase , autocrine signalling , paracrine signalling , microbiology and biotechnology , arachidonic acid , second messenger system , enzyme , intracellular , biochemistry , chemistry , lipid signaling , leukotriene b4 , calcium in biology , biology , inflammation , receptor , immunology , asthma
Leukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are synthesized from arachidonic acid by the 5‐lipoxygenase pathway. Current models of this enzymatic pathway recognize that a key step in initiating leukotriene synthesis is the calcium‐mediated movement of enzymes, including 5‐lipoxygenase, to intracellular membranes. However, 5‐lipoxygenase can be imported into or exported from the nucleus before calcium activation. As a result, its subcellular localization will affect its ability to be activated by calcium, as well as the membrane to which it binds and its interaction with other enzymes. This commentary focuses on the role of 5‐lipoxygenase compartmentation in determining its regulation and, ultimately, leukotriene synthesis. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.