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Inner nuclear membrane and signal transduction
Author(s) -
Worman Howard J.
Publication year - 2005
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20650
Subject(s) - inner membrane , signal transduction , transduction (biophysics) , microbiology and biotechnology , nucleus , biology , cell nucleus , nuclear membrane , cell membrane , cell , genetics , biochemistry , mitochondrion
Recent research has shown that the inner nuclear membrane is a site for regulation of signal transduction from the plasma membrane to the nucleus. This has coincided with discoveries showing that mutations in extrinsic and intrinsic inner nuclear membrane proteins cause a variety of inherited diseases. In most instances, the mechanisms by which mutations in inner nuclear membrane proteins cause disease are not understood. In at least one case, however, an alteration in signal transduction appears to underlie disease pathogenesis. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.