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Indian hedgehog: Its roles and regulation in endochondral bone development
Author(s) -
Lai Lick Pui,
Mitchell Jane
Publication year - 2005
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20635
Subject(s) - indian hedgehog , morphogen , endochondral ossification , chondrocyte , hedgehog , parathyroid hormone related protein , microbiology and biotechnology , endocrinology , cartilage , chondrogenesis , medicine , hedgehog signaling pathway , biology , anatomy , parathyroid hormone , signal transduction , calcium , genetics , gene
Normal endochondral bone development requires the coordination of chondrocyte proliferation and differentiation. Indian hedgehog (Ihh) is a morphogen produced by chondrocytes in the early stage of terminal differentiation and plays several key roles in this process. Ihh regulates growth of adjacent proliferative chondrocytes and can also regulate the rate of differentiation of chondrocytes indirectly through its stimulation of parathyroid hormone‐related protein (PTHrP). In this review, we focus on recent studies that have identified new functions of Ihh and how Ihh itself is being regulated. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.