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Histone modifying enzymes and cancer: Going beyond histones
Author(s) -
Zhang Ke,
Dent Sharon Y.R.
Publication year - 2005
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20615
Subject(s) - histone , acetylation , chromatin remodeling , histone modifying enzymes , microbiology and biotechnology , chromatin , carcinogenesis , histone methyltransferase , histone h2a , biology , chemistry , cancer , biochemistry , genetics , dna , gene
Mutations in the molecular pathways that regulate cell proliferation, differentiation, and cell death all contribute to cancer formation. Enzymes that covalently modify histones affect these pathways by controlling the dynamic remodeling of chromatin structure. This article reviews several connections between histone modifying enzymes and cancer that are likely mediated via both histone and non‐histone substrates. We propose that multiple protein modifications, including phosphorylation, methylation, and acetylation, cross regulate one another to coordinate intermolecular signaling, and that miscues in this regulation can lead to oncogenesis. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.