Premium
Nuclear inositol lipid metabolism: More than just second messenger generation?
Author(s) -
Martelli Alberto M.,
Follo Matilde Yung,
Evangelisti Camilla,
Falà Federica,
Fiume Roberta,
Billi Anna Maria,
Cocco Lucio
Publication year - 2005
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20527
Subject(s) - second messenger system , inositol , phosphatidylinositol , microbiology and biotechnology , biology , phosphoinositide phospholipase c , myeloid leukemia , nucleus , dna replication , transcription factor , transcription (linguistics) , gene , signal transduction , biochemistry , receptor , cancer research , linguistics , philosophy
A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcription, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings strongly indicate that lipids present in the nucleus also fulfil other roles. The scope of this review is to highlight the most intriguing advances made in the field over the last few years, such as the possibility that nuclear phosphatidylinositol (4,5) bisphosphate is involved in maintaining chromatin in a transcriptionally active conformation, the new emerging roles for intranuclear phosphatidylinositol (3,4,5) trisphosphate and phosphoinositide 3‐kinase, and the evidence which suggests a tight relationship between a decreased level of nuclear phosphoinositide specific phospholipase C‐β1 and the evolution of myelodisplastic syndrome into acute myeloid leukemia. © 2005 Wiley‐Liss, Inc.