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Control of RUNX2 isoform expression: The role of promoters and enhancers
Author(s) -
Stock Michael,
Otto Florian
Publication year - 2005
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20471
Subject(s) - enhancer , promoter , biology , runx2 , gene isoform , gene , transcription factor , genetics , regulation of gene expression , gene expression , regulatory sequence , transcriptional regulation , transcription (linguistics) , microbiology and biotechnology , linguistics , philosophy
The three mammalian RUNX genes constitute the family of runt domain transcription factors that are involved in the regulation of a number of developmental processes such as haematopoiesis, osteogenesis and neuronal differentiation. All three genes show a complex temporo‐spatial pattern of expression. Since the three proteins are probably mutually interchangeable with regard to function, most of the specificity of each family member seems to be based on a tightly controlled regulation of expression. While RUNX gene expression is driven by two promoters for each gene, the promoter sequence alone does not seem to suffice for a proper expressional control. This review focuses on the available evidence for the existence of such control mechanisms and studies aiming at discovering cis ‐acting regulatory sequences of the RUNX 2 gene. © 2005 Wiley‐Liss, Inc.