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Effect of N‐cadherin misexpression by the mammary epithelium in mice
Author(s) -
Knudsen Karen A.,
Sauer Christa,
Johnson Keith R.,
Wheelock Margaret J.
Publication year - 2005
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20469
Subject(s) - cadherin , biology , epithelium , mammary gland , genetically modified mouse , cancer research , pathology , transgene , cell , cancer , gene , breast cancer , medicine , genetics
N‐cadherin is not typically expressed by epithelial cells. However, it is detected in breast cancers and increases tumor cell migration and invasion in vitro. To explore its misexpression, we generated transgenic mice with N‐cadherin in the mammary epithelium. Mammary glands appeared normal and no tumors arose spontaneously. To investigate N‐cadherin misexpression in mammary tumors, neu was overexpressed through breeding. Tumors developed in +/ neu and N‐cadherin/ neu mice, although few tumors in bitransgenic mice expressed N‐cadherin, and they did not differ from N‐cadherin‐negative tumors. © 2005 Wiley‐Liss, Inc.