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Imprinting centers, chromatin structure, and disease
Author(s) -
Soejima Hidenobu,
Wagstaff Joseph
Publication year - 2005
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20443
Subject(s) - chromatin , imprinting (psychology) , computational biology , biology , genetics , evolutionary biology , microbiology and biotechnology , dna , gene
Two regions that best exemplify the role of genetic imprinting in human disease are the Prader–Willi syndrome/Angelman syndrome (PWS/AS) region in 15q11‐q13 and the Beckwith–Wiedemann syndrome (BWS) region in 11p15.5. In both regions, cis‐acting sequences known as imprinting centers (ICs) regulate parent‐specific gene expression bidirectionally over long distances. ICs for both regions are subject to parent‐specific epigenetic marking by covalent modification of DNA and histones. In this review, we summarize our current understanding of IC function and IC modification in these two regions. © 2005 Wiley‐Liss, Inc.