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Rho‐GTPases: New members, new pathways
Author(s) -
Sorokina Elena M.,
Chernoff Jonathan
Publication year - 2005
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20327
Subject(s) - gtpase , biology , microbiology and biotechnology , cytoskeleton , actin cytoskeleton , signal transduction , actin , gene , genetics , cell
Proteins comprising the Rho family of GTPases mediate reorganization of the actin cytoskeleton as well as transcription of genes. Recent findings from genome sequencing efforts, genetic screens, and signal transduction research have revealed that the Rho family contains several new, hitherto unrecognized members. In this review, we focus on these newly discovered Rho‐GTPases and discuss their role in signaling to the cytoskeleton and the nucleus. © 2004 Wiley‐Liss, Inc.