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Diversity of antisense regulation in eukaryotes: Multiple mechanisms, emerging patterns
Author(s) -
Munroe Stephen H.
Publication year - 2004
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20252
Subject(s) - biology , multicellular organism , rna , gene , antisense rna , microrna , computational biology , genetics , long non coding rna , transcriptome , non coding rna , function (biology) , regulation of gene expression , gene expression
High‐throughput analysis of RNA molecules in multicellular eukaryotes has revealed an abundance of complementary antisense RNAs that are transcribed from separate or overlapping genes. In mammals these include many novel non‐coding RNAs of unknown function. This unexpected complexity of the mammalian transcriptome suggests that expression of many genes is regulated post‐transcriptionally by mechanisms mediated by RNA–RNA base pairing. The recent discovery of the widespread expression of microRNAs in animals and plants provides a prototypic example of such regulation in eukaryotes. However, there are likely to be numerous other types of antisense regulation in eukaryotes, many as yet uncharacterized. © 2004 Wiley‐Liss, Inc.