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RNA binding motif (RBM) proteins: A novel family of apoptosis modulators?
Author(s) -
Sutherland Leslie C.,
RintalaMaki Nina D.,
White Ryan D.,
Morin Cory D.
Publication year - 2004
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20204
Subject(s) - rna binding protein , rna recognition motif , rna , biology , sequence motif , apoptosis , genetics , microbiology and biotechnology , computational biology , gene
RBM5 is a known modulator of apoptosis, an RNA binding protein, and a putative tumor suppressor. Originally identified as LUCA‐15, and subsequently as H37, it was designated “RBM” (for RNA Binding Motif) due to the presence of two RRM (RNA Recognition Motif) domains within the protein coding sequence. Recently, a number of proteins have been attributed with this same RBM designation, based on the presence of one or more RRM consensus sequences. One such protein, RBM3, was also recently found to have apoptotic modulatory capabilities. The high sequence homology at the amino acid level between RBM5, RBM6, and particularly, RBM10 suggests that they, too, may play an important role in regulating apoptosis. It is the intent of this article to ammalgamate the data on the ten originally identified RBM proteins in order to question the existence of a novel family of RNA binding apoptosis regulators. © 2004 Wiley‐Liss, Inc.