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Bone morphogenetic proteins in vertebrate hematopoietic development
Author(s) -
Snyder Alexandra,
Fraser Stuart T.,
Baron Margaret H.
Publication year - 2004
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20191
Subject(s) - haematopoiesis , bone morphogenetic protein , microbiology and biotechnology , biology , embryonic stem cell , stem cell , hematopoietic stem cell , cord blood , embryogenesis , immunology , embryo , genetics , gene
During embryonic development, the hematopoietic system is the first to generate terminally differentiated, functional cell types. The urgent necessity for the early formation of blood and blood vessels during embryogenesis means that the induction, expansion, and maturation of these systems must be rapidly and precisely controlled. Bone morphogenic proteins (BMPs) have been implicated in hematopoietic development in the vertebrate embryo and stimulate the proliferation and/or differentiation of human cord blood hematopoietic stem cells (HSC) and embryonic stem cells in vitro. Here we review the mechanisms of action and potential roles of these soluble signaling molecules in vertebrate hematopoiesis. © 2004 Wiley‐Liss, Inc.