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Ime2p and Cdc28p: Co‐pilots driving meiotic development
Author(s) -
Honigberg Saul M.
Publication year - 2004
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20131
Subject(s) - aeronautics , meiosis , business , biology , engineering , genetics , gene
Meiosis can be considered an elaboration of the cell division cycle in the sense that meiosis combines cell‐cycle processes with programs specific to meiosis. Each phase of the cell division cycle is driven forward by cell‐cycle kinases (Cdk) and coordinated with other phases of the cycle through checkpoint functions (Hartwell and Weinert [1989]: Science. 246:629–634). Meiotic differentiation is also controlled by these two types of regulation (Murakami and Nurse [2000]: Biochem J. 349:1–12; Roeder and Bailis [2000]: Trends Genet. 16:395–403); however, recent study in the budding yeast S. cerevisiae indicates that progression of meiosis is also controlled by a master regulator specific to meiosis, namely the Ime2p kinase (Benjamin et al. [2003]: Genes Dev. 17:1–16; Schindler et al. [2003]: Mol Cell Biol 23:8718–8728). Below, I describe the overlapping roles of Ime2p and Cdk during meiosis in yeast and speculate on how these two kinases cooperate to drive the progression of meiosis. © 2004 Wiley‐Liss, Inc.