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Tau isoforms which contain the domain encoded by exon 6 and their role in neurite elongation
Author(s) -
Luo Minhua,
Leski Michael L.,
Andreadis Athena
Publication year - 2004
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.20029
Subject(s) - exon , neurite , gene isoform , alternative splicing , rna splicing , neurodegeneration , microbiology and biotechnology , biology , morphogenesis , tangle , genetics , rna , gene , medicine , mathematics , disease , pure mathematics , in vitro , pathology
Abstract The regulation of tau protein expression during different stages of cellular differentiation and development as well as its functional role in morphogenesis, neurofibrillary tangle formation, and neurodegeneration have been topics of extensive study but have not been completely clarified yet. Tau undergoes complex regulated splicing in the mammalian nervous system. Our previous study with tau exon 6 demonstrated that it shows a splicing regulation profile which is distinct from that of the other tau exons as well as a unique expression pattern which is spatially and temporally regulated. In this study, we investigated the expression, localization, and effects of tau isoforms which contain exon 6 in neuroblastoma cells which stably overexpress them. We found that expression of one particular combination of tau exons (the longest adult isoform plus the domain of exon 6) significantly inhibits neurite elongation. © 2004 Wiley‐Liss, Inc.