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Nuclear estrogen receptor II (nER‐II) is involved in the estrogen‐dependent ribonucleoprotein transport in the goat uterus I. Localization of nER‐II in snRNP
Author(s) -
Sebastian Thomas,
Thampan Raghava Varman
Publication year - 2001
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.1279
Subject(s) - ribonucleoprotein , estrogen receptor , small nuclear ribonucleoprotein , estrogen , nuclear receptor , snrnp , estrogen receptor beta , microbiology and biotechnology , estrogen receptor alpha , chemistry , biology , endocrinology , rna , biochemistry , genetics , gene , transcription factor , cancer , breast cancer
Exposure of goat uterine nuclei to estradiol in vitro results in an immediate exit of ribonucleoproteins (RNP) from the nuclei to the medium. This RNP exit appears to be mediated by an estrogen receptor localized in small nuclear ribonucleoproteins containing U1 and U2 snRNA. Available evidence indicates that the estrogen receptor involved is not the ERα, but an alternative form, which is also a 66 kDa protein. This is the nuclear estrogen receptor II (nER‐II) that has no DNA‐binding capacity. The transport is estrogen‐specific since non‐estrogenic steroids do not stimulate the transport of the RNP where the receptor is localized. J. Cell. Biochem. 84: 217–226, 2002. © 2001 Wiley‐Liss, Inc.