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Seasonal environmental changes modulate the prolactin receptor expression in an eurythermal fish
Author(s) -
San Martín Rody,
Cáceres Pilar,
Azócar Rodrigo,
Alvarez Marco,
Molina Alfredo,
Vera María I.,
Krauskopf Manuel
Publication year - 2004
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10791
Subject(s) - biology , prolactin receptor , prolactin , carp , acclimatization , receptor , homeostasis , microbiology and biotechnology , hormone , endocrinology , fish <actinopterygii> , ecology , genetics , fishery
Abstract Eurythermal fish have evolved compensatory responses to the cyclical seasonal changes of the environment. The complex adaptive mechanisms include the transduction of the physical parameters variations into molecular signals. Studies in carp have indicated that prolactin and growth hormone expression is associated with acclimatization, suggesting that the pituitary gland is a relevant physiological node in the generation of the homeostatic rearrangement that occurs in this adaptive process. Here, we report the cloning and characterization of a full‐length carp prolactin receptor cDNA, which codes for the long form of the protein resembling that found in mammalian prolactin receptors. We identified up to three receptor transcript isoforms in different tissues of the teleost and assessed cell‐ and temporal‐specific transcription and protein expression in carp undergoing seasonal acclimatization. The distinctive pattern of expression that carp prolactin receptor (cPRLr) depicts upon seasonal acclimatization supports the hypothesis that prolactin and its receptor are clearly involved in the new homeostatic stage that the eurythermal fish needs to survive during the cyclical changes of its habitat. © 2004 Wiley‐Liss, Inc.