Premium
Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation
Author(s) -
Stein Gary S.,
Lian Jane B.,
van Wijnen Andre J.,
Stein Janet L.,
Javed Amjad,
Montecino Martin,
Zaidi S. Kaleem,
Young Daniel,
Choi JeYong,
Gutierrez Soraya,
Pockwinse Shirwin
Publication year - 2004
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10777
Subject(s) - microbiology and biotechnology , nuclear transport , cell growth , biology , cell nucleus , genetics , nucleus
Abstract The temporal and spatial organization of transcriptional regulatory machinery provides microenvironments within the nucleus where threshold concentrations of genes and cognate factors facilitate functional interactions. Conventional biochemical, molecular, and in vivo genetic approaches, together with high throughput genomic and proteomic analysis are rapidly expanding our database of regulatory macromolecules and signaling pathways that are requisite for control of genes that govern proliferation and differentiation. There is accruing insight into the architectural organization of regulatory machinery for gene expression that suggests signatures for biological control. Localized scaffolding of regulatory macromolecules at strategic promoter sites and focal compartmentalization of genes, transcripts, and regulatory factors within intranuclear microenvironments provides an infrastructure for combinatorial control of transcription that is operative within the three dimensional context of nuclear architecture. © 2003 Wiley‐Liss, Inc.