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Hyperplasia, partial hepatectomy, and the carcinogenicity of aflatoxin B 1
Author(s) -
Roebuck B.D.
Publication year - 2003
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10758
Subject(s) - hepatectomy , hyperplasia , carcinogen , aflatoxin , carcinogenesis , liver cancer , hepatotoxin , cancer research , medicine , cancer , pathology , biology , toxicity , resection , surgery , biochemistry , food science
Generalized cellular hyperplasia has long been associated as a factor in the causation of liver cancer. Parenchymal cell hyperplasia resulting from hepatotoxins, viruses, parasites, or malnutrition is exceedingly variable as to when it occurs, its extent, and its duration. Partial hepatectomy has been used as an experimental tool precisely because the timing and extent of hyperplasia can be known and controlled. With regards to aflatoxin B 1 (AFB 1 ) carcinogenesis, partial hepatectomy has produced variable results. An explanation appears to reside in the hepatotoxic properties of AFB 1 that enhance the early stages of carcinogenesis. © 2003 Wiley‐Liss, Inc.