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In vivo imaging and tumor therapy with the sodium iodide symporter
Author(s) -
Dingli David,
Russell Stephen J.,
Morris John C.
Publication year - 2003
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10714
Subject(s) - sodium iodide symporter , genetic enhancement , biodistribution , symporter , reporter gene , vector (molecular biology) , cancer research , in vivo , gene , molecular imaging , computational biology , gene expression , viral vector , medicine , biology , genetics , transporter , recombinant dna
There has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non‐invasively the biodistribution, gene expression and replication of these viral vector systems. With the advent of molecular imaging technology, this deficiency is being rapidly rectified. A number of reporter genes have been used to monitor gene expression. In this review, we discuss the role of the sodium iodide symporter (NIS) as a reporter and therapeutic gene for cancer gene therapy when combined with various radioactive isotopes. © 2003 Wiley‐Liss, Inc.