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Emerging views of integrin signaling: Implications for prostate cancer
Author(s) -
SlackDavis Jill K.,
Parsons J. Thomas
Publication year - 2003
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10665
Subject(s) - integrin , prostate cancer , signal transduction , metastasis , carcinogenesis , cancer research , cell adhesion , biology , microbiology and biotechnology , transmembrane protein , cell migration , cell , receptor , cancer , genetics
Abstract Integrins are heterodimeric transmembrane cellular receptors that link the cell to its underlying substratum. Alterations in integrin expression and signaling have been implicated in many aspects of tumorigenesis and metastasis including cell survival, migration, and invasion. In prostate cancer, the progression from normal to metastatic cells is accompanied by changes in the repertoire of integrins expressed and up‐regulation of key adhesion‐dependent signaling pathways. Recent work from several laboratories indicates the emergence of new mechanisms for the regulation of growth and migratory pathways by integrin engagement. These pathways are likely to provide novel sites of therapeutic intervention for the treatment of prostate cancer. © 2003 Wiley‐Liss, Inc.