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Antisense imaging: And miles to go before we sleep?
Author(s) -
Lewis Michael R.,
Jia Fang
Publication year - 2003
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10641
Subject(s) - molecular imaging , oligonucleotide , messenger rna , gene expression , in vivo , computational biology , rna , antisense rna , gene , biology , microbiology and biotechnology , chemistry , nanotechnology , genetics , materials science
Labeled oligonucleotide analogues for antisense imaging of messenger RNA (mRNA) have great potential for detection of endogenous gene expression in vivo. Successful antisense imaging may be useful for detecting cellular gene expression patterns and early molecular changes in disease. Conclusive demonstration of this technique has been hindered by formidable challenges in surmounting biological barriers and detecting low concentrations of target mRNA. Recent advances in the development of novel antisense molecules, high specific activity radiolabeling chemistry, sophisticated drug targeting technology, and complementary molecular imaging modalities make it quite possible that true antisense imaging will be realized in the near future. © 2003 Wiley‐Liss, Inc.