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Proteomics in biomarker discovery and drug development
Author(s) -
He QingYu,
Chiu JenFu
Publication year - 2003
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10576
Subject(s) - proteomics , biomarker discovery , proteome , biomarker , computational biology , drug development , drug discovery , identification (biology) , quantitative proteomics , bioinformatics , biology , drug , pharmacology , genetics , botany , gene
Proteomics is a research field aiming to characterize molecular and cellular dynamics in protein expression and function on a global level. The introduction of proteomics has been greatly broadening our view and accelerating our path in various medical researches. The most significant advantage of proteomics is its ability to examine a whole proteome or sub‐proteome in a single experiment so that the protein alterations corresponding to a pathological or biochemical condition at a given time can be considered in an integrated way. Proteomic technology has been extensively used to tackle a wide variety of medical subjects including biomarker discovery and drug development. By complement with other new technique advances in genomics and bioinformatics, proteomics has a great potential to make considerable contribution to biomarker identification and to revolutionize drug development process. This article provides a brief overview of the proteomic technologies and their application in biomarker discovery and drug development. J. Cell. Biochem. 89: 868–886, 2003. © 2003 Wiley‐Liss, Inc.