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Introduction to the physics of molecular imaging with radioactive tracers in small animals
Author(s) -
King Michael A.,
Pretorius P. Hendrik,
Farncombe Troy,
Beekman Freek J.
Publication year - 2002
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10447
Subject(s) - positron emission tomography , physics , tomographic reconstruction , positron , positron emission , gamma ray , emission computed tomography , molecular imaging , single photon emission computed tomography , pet imaging , tomography , medical physics , nuclear medicine , optics , nuclear physics , medicine , biology , microbiology and biotechnology , electron , in vivo
Recent advances have greatly enhanced the three‐dimensional (3D) imaging of radioactive tracers in living animals. this article introduces the physics of imaging behind the imaging methods. The article first discusses the selection of the radiation emitted from the tracer and then the process of tomographic reconstruction or how 3D images are made from imaging around the outside of the animal. The technique of single photon emission computed tomography (SPECT) in which the detection of one X‐ray or gamma ray at a time is employed for image formation is then described. Finally, positron emission tomography (PET) which relies on the simultaneous detection of the pair of gamma‐rays formed when the positron annihilates is presented. J. Cell. Biochem. Suppl. 39: 221–230, 2002. © 2002 Wiley‐Liss, Inc.