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Effects of 1α,25(OH) 2 D 3 and its analogs on dendritic cell function
Author(s) -
Griffin Matthew D.,
Kumar Rajiv
Publication year - 2003
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10335
Subject(s) - dendritic cell , immune system , vitamin d and neurology , receptor , microbiology and biotechnology , in vivo , chemistry , in vitro , vitamin , calcitriol receptor , biology , follicular dendritic cells , lymph node , endocrinology , medicine , t cell , antigen presenting cell , biochemistry , immunology , genetics
1α,25‐Dihydroxyvitamin D 3 (1α,25(OH) 2 D 3 ) and non‐calcemic vitamin D analogs induce a persistent state of immaturity in dendritic cells both in vitro and in vivo. These effects are transcriptional in nature, involve alterations in surface ligands as well as cytokine synthesis and release, and are dependent upon the presence of the vitamin D receptor. The vitamin D endocrine system could also play a role in altering immune function in normal physiological conditions. Distinct differences exist in lymph node dendritic cells of vitamin D receptor null mutant mice when compared to normal mice. J. Cell. Biochem. 88: 323–326, 2003. © 2002 Wiley‐Liss, Inc.