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Does PTH have a direct effect on intestine?
Author(s) -
Nemere I.,
Larsson D.
Publication year - 2002
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10199
Subject(s) - parathyroid hormone , vitamin d and neurology , endocrinology , small intestine , medicine , calcium , receptor , chemistry , calcium metabolism , hormone , calcitriol receptor , biology
Dogma for the past three decades has dictated that parathyroid hormone (PTH) has no direct effect on intestine with regard to calcium or phosphate absorption, but rather that PTH acts to promote the synthesis of a hormonally active form of vitamin D, namely 1,25‐dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ]. However, diverse laboratories have each provided some evidence to suggest PTH does indeed have a direct effect on intestine. We will briefly review the evidence for biological effects, biochemical effects, and the presence of intestinal receptors for PTH, and conclude with the implications for biomedical research. J. Cell. Biochem. 86: 29–34, 2002. © 2002 Wiley‐Liss, Inc.