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Computational method to assign microbial genes to pathways
Author(s) -
Pellegrini Matteo,
Thompson Michael,
Fierro Joseph,
Bowers Peter
Publication year - 2001
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10071
Subject(s) - gene , biology , genome , computational biology , genetics , biological pathway , gene expression
We present techniques that mine fully sequenced microbial genomes for functional relationships between genes. We show that genes related by one of four techniques are more likely to belong to the same cellular pathways. Furthermore, we demonstrate that the pathway of an uncharacterized gene may be inferred from those of its functionally related partners. Therefore, we are now able to assign most of the genes within bacteria to cellular pathways. J. Cell. Biochem. Suppl. 37: 106–109, 2001. © 2002 Wiley‐Liss, Inc.