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Detection of SV40 DNA sequences in malignant mesothelioma specimens from the United States, but not from Turkey
Author(s) -
De Rienzo Assunta,
Tor Meltem,
Sterman Daniel H.,
Aksoy Ferda,
Albelda Steven M.,
Testa Joseph R.
Publication year - 2002
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10058
Subject(s) - mesothelioma , asbestos , virus , simian , dna , virology , incidence (geometry) , biology , etiology , pathology , medicine , genetics , optics , physics , metallurgy , materials science
The incidence of malignant mesothelioma (MM) shows a strong epidemiological association with exposure to asbestos fibers. Recently, simian virus 40 (SV40) DNA sequences have been reported in MM tumor specimens from the United States and several European countries, and the SV40 tumor virus has been implicated as a potential co‐factor in the etiology of this disease. However, several large studies from the US, Finland, and Turkey did not detect SV40 sequences in MM samples. To address this discrepancy, MM specimens from Turkey and the US were analyzed in the same laboratory under identical conditions to detect the presence of SV40 DNA. We detected SV40 sequences in 4 of 11 specimens from the United States, but in none of the 9 Turkish samples examined. These findings suggest that geographical differences exist with regard to the involvement of SV40 in human tumors. J. Cell. Biochem. 84: 455–459, 2002. © 2001 Wiley‐Liss, Inc.