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Mesenchymal stem cells: Will they have a role in the clinic?
Author(s) -
Devine Steven M.
Publication year - 2002
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.10046
Subject(s) - mesenchymal stem cell , stem cell , clinical uses of mesenchymal stem cells , haematopoiesis , bone marrow , stem cell transplantation for articular cartilage repair , population , biology , immunology , medicine , cancer research , microbiology and biotechnology , adult stem cell , in vitro , endothelial stem cell , genetics , environmental health
In addition to hematopoietic stem cells (HSC), human post natal bone marrow contains another stem cell capable of giving rise to multiple mesenchymal cell lineages. Termed mesenchymal stem cells (MSCs) based on their capacity for multi‐lineage differentiation, these cells can easily be obtained following a simple bone marrow aspiration procedure and subsequently expanded in culture through as many as 50 population doublings. This extensive capacity for expansion in vitro at clinical scale has recently facilitated the development of clinical trials designed to assess the safety, feasibility, and efficacy of transplanting MSC for a variety of pathological conditions. This review focuses on the background and rationale for performing clinical studies of MSC transplantation and will discuss the potential role that MSC may play in the correction or modification of human diseases. J. Cell. Biochem. Suppl. 38: 73–79, 2002. © 2002 Wiley‐Liss, Inc.