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Decrease of thyroid hormones in patients with familial hypercholesterolemia during dextran sulphate low‐density lipoprotein apheresis
Author(s) -
Pintus S.,
Pintus P.,
Piras C.,
Loviselli A.,
Muntoni S.
Publication year - 1994
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.2920090206
Subject(s) - medicine , apheresis , hormone , lipoprotein , familial hypercholesterolemia , plasma lipoprotein , endocrinology , thyroid , thyroid hormones , dextran , ldl apheresis , low density lipoprotein , cholesterol , chromatography , chemistry , platelet
Removal of low‐density lipoproteins from plasma by dextran sulfate adsorption (DSA) in FH patients entails a decrease in plasma levels of thyroid hormones (−28.5% and −18.7%, respectively, for T3 and T4). This suggests that FH patients have a greater than normal fraction of thyroid hormones bound to lipoproteins, due to their expanded lipoprotein pool.