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Therapeutic cytoreduction in a 7‐month‐old baby with acute leukemia
Author(s) -
Huestis Douglas W.,
Hutter John J.,
James Peggy
Publication year - 1992
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.2920070406
Subject(s) - medicine , leukostasis , leukapheresis , buffy coat , white blood cell , chemotherapy , leukemia , carboplatin , surgery , cd34 , stem cell , cisplatin , biology , genetics
A 7‐month‐old girl with acute biphenotypic leukemia [t(4;11)] had accompanying anemia, thrombocytopenia, and a white blood cell count of 535,000/μL with 98% blasts. Before instituting chemotherapy, therapeutic leukapheresis was done to reduce the threat of complications from leukostasis. Using a Cobe Spectra blood cell separator primed with modified blood, we processed 1,395 mL of her blood, removing 201 mL of the buffy coat containing 5.8 × 10 10 white blood cells. This reduced the WBC count to 301,000/μL. Only a single procedure was done, without significant complications. The rationale of this preparatory cytoreduction is discussed critically. Subsequent chemotherapy resulted in a long‐lasting remission. © 1992 Wiley‐Liss, Inc.