Artificial surfaces in apheresis devices: Interactions with the complement system | Zendy

Malchesky Paul S. | Zendy

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Artificial surfaces in apheresis devices: Interactions with the complement system

Author(s) -

Malchesky Paul S.

Publication year - 1992

Publication title -

journal of clinical apheresis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.697

H-Index - 46

eISSN - 1098-1101

pISSN - 0733-2459

DOI - 10.1002/jca.2920070310

Subject(s) - apheresis , citation , medicine , foundation (evidence) , corporation , complement (music) , library science , operations research , computer science , engineering , law , immunology , complementation , political science , gene , phenotype , biochemistry , platelet , chemistry

Blood contacts with artificial surfaces will effect different degrees of complement activation. Associated with complement activation will be cellular concentration and functional changes. The type of anticoagulant also will effect complement activation. The noted biomodulating effect of a material in contact with blood suggests that the choice and design of materials and their "biocompatibility" can be made to effect humoral and cellular changes as the therapy may require.

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