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Complete remission of paraneoplastic sensorimotor neuropathy: A case associated with small‐cell lung cancer responsive to chemotherapy, plasma exchange, and radiotherapy
Author(s) -
Weissman David E.,
Gottschall Jerome L.
Publication year - 1989
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.2920050104
Subject(s) - medicine , chemotherapy , radiation therapy , peripheral neuropathy , lung cancer , cancer , surgery , endocrinology , diabetes mellitus
A 61‐year‐old man was found to have small‐cell lung cancer following a 1‐year history of a progressive peripheral sensorimotor neuropathy. The neuropathy initially improved following chemotherapy, but subsequently progressed to the point of respiratory failure. Treatment with plasma exchange, additional chemotherapy, and radiotherapy resulted in a sustained complete tumor remission and neurologic recovery. The role of plasma exchange is unclear, but its use should be considered in cases of severe sensorimotor neuropathy unresponsive to antineoplastic treatment.