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Remission of hyper‐lgE syndrome treated with plasmapheresis and cytotoxic immunosuppression
Author(s) -
Dau Peter C.
Publication year - 1988
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.2920040104
Subject(s) - plasmapheresis , medicine , immunosuppression , immunoglobulin e , cytotoxic t cell , immunology , cd8 , immune system , antibody , biochemistry , chemistry , in vitro
A patient with a hyper‐IgE syndrome was treated with 60 plasmaphereses over a period of 2 years in conjunction with cytotoxic immunosuppressive drug therapy. During this time her severe dermatitis of 8 years' duration became almost completely inactive, and her circulating IgE level was reduced by 73%. An elevated pretreatment ratio of CD4 + /CD8 + T lymphocytes fell to subnormal. The beneficial results of treatment may be attributed to the reduction of lymphocyte populations responsible for IgE production by the combined action of plasmapheresis and of cytotoxic drugs as well as the direct effect of removal of circulating IgE and possibly IgE‐potentiating factors.