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Aluminium loading during therapeutic plasma exchange
Author(s) -
Monteagudo Felix,
Wood Lucille,
Jacobs Peter,
Folb Peter,
Cassidy Michael
Publication year - 1987
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.2920030306
Subject(s) - medicine , therapeutic plasma exchange , intensive care medicine , aluminium , plasmapheresis , surgery , immunology , metallurgy , antibody , materials science
Abstract Graphite furnace atomic absorption spectroscopy was used to demonstrate a fivefold increase in the median plasma aluminium levels of four patients undergoing therapeutic plasmapheresis. This plasma aluminium loading resulted from contamination of albumin incorporated in the replacement fluids and took place during its preparation, with albumin aluminium levels of 646, 669, and 715 μg/liter present in three representative samples. Aluminium overload may result in the development of encephalopathy and osteomalacia in patients with renal impairment, indicating the need to monitor aluminium levels in the albumin‐containing replacement fluids to avoid this potential hazard.