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Effect of plasmapheresis on E‐rosette receptors in sle patients
Author(s) -
Vangelista Alba,
Frascà Giovanni M.,
NanniCosta Alessandro,
Bonomini Vittorio
Publication year - 1986
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.2920030204
Subject(s) - plasmapheresis , rosette (schizont appearance) , medicine , antibody , receptor , monoclonal antibody , immunology , fc receptor , rosette formation , immunotherapy , immune system
The present study reports on the effects of plasmapheresis on both cellular (E‐rosette receptor‐ and Fc receptor‐bearing lymphocytes) and humoral (antilymphocyte antibodies) immunity in patients with active SLE. Ten untreated patients were studied before and after two plasma exchanges. The E‐rosette receptor‐positive cells were studied by OKT11 monoclonal antibody and Fc receptor‐bearing cells by Leu 15 monoclonal antibody. Antilymphocyte antibodies were studied before and after plasma exchange by an indirect immunofluorescence technique on autologous and normal lymphocytes. A reduction in OKT11 + and Leu 15 + lymphocytes was observed in all patients before plasmapheresis. Antilymphocyte antibodies were detected in five patients. After plasma exchange, an increase in E‐rosette receptor‐ and Fc receptor‐bearing lymphocytes was observed along with a reduction in the amount of antilymphocyte antibodies.