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Controlled trial of plasma exchange in acute inflammatory polyradiculoneuropathy
Author(s) -
Greenwood R. J.,
Hughes R. A. C.,
Bowden A. N.,
Gordon N. S.,
Millac P.,
Davis J. Newsom,
Asian S.,
Chadwick D. W.,
McLellan D. L.,
Stott R. B.
Publication year - 1985
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.2920020420
Subject(s) - medicine , polyradiculoneuropathy , randomized controlled trial , therapeutic plasma exchange , surgery , pediatrics , guillain barre syndrome
Abstract A randomized controlled trial of exchange versus no exchange was conducted to find out whether plasma exchange would be useful in acute inflammatory polyradiculoneuropathy. It was calculated that 15 patients would be required in each group to demonstrate a worthwhile improvement in functional ability one month after completion of treatment. Treatment comprised five exchanges in 10 days (55 ml plasma/kg body weight/exchange). Both groups received normal supportive care and were followed up periodically for a year. Overall the treated group showed a slight but not significant benefit (p>0.05); at two weeks' follow‐up of patients admitted to the trial within 14 days of onset of neuropathic symptoms, p=0.07. These results do not provide grounds for recommending plasma exchange for the treatment of severe AIP.