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Plasmapheresis versus lymphoplasmapheresis in rheumatoid arthritis: Immunologic comparisons and literature review
Author(s) -
Wallace Daniel J.,
Medici Michael A.,
Nichols Sherri,
Klinenberg James R.,
Brck Miriam,
Gatti Richard,
Goidfinger Dennis
Publication year - 1984
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.2920020207
Subject(s) - medicine , plasmapheresis , rheumatoid arthritis , immunology , intensive care medicine , antibody
Eight patients with Functional Class III. seropositive, erosive rheumatoid arthritis unresponsive to remittive drugs each underwent nine aphereses over 3 weeks. Four had a 40‐ml/kg plasma exchange and four others had a 40‐ml/ kg plasma exchange plus a mean 5.67 × 10 9 lymphocyte depletion. Both groups appeared to improve clinically. T and B cell counts and OK T4 and OK T8 ratios decreased in the lymphoplasmapheresis group. Phytohemagglutinin stimulation decreased in lymphoplasmapheresis and increased in plasmapheresis patients with significant comparisons (p = 0.02). These findings confirm and extend previous work. Plasmapheresis and lymphoplasmapheresis appear to have fundamentally different actions on lymphocyte function.