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Plasmapheresis in lupus nephritis with nephrotic syndrome: A long‐term followup
Author(s) -
Wallace Daniel J.,
Goldfinger Dennis,
Bluestone Rodney,
Klinenberg James R.
Publication year - 1982
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.2920010109
Subject(s) - medicine , plasmapheresis , lupus nephritis , nephrotic syndrome , azathioprine , cyclophosphamide , refractory (planetary science) , systemic lupus erythematosus , nephritis , gastroenterology , immunology , dermatology , chemotherapy , disease , antibody , physics , astrobiology
Lupus nephritis with nephrotic syndrome is one of the most serious complications of systemic lupus erythematosus. Six female patients with systemic lupus and nephrotic syndrome, refractory to immunosuppressive drug therapy, received 15–20 exchange plasmaphereses. One patient, treated concurrently with high‐dose steroids, showed temporary improvement, and five patients, treated concurrently with steroids and either cyclophosphamide or azathioprine, had long‐term remissions. Plasmapheresis is a promising therapeutic modality in cases of refractory lupus nephritis with nephrotic syndrome.