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The role of treatment with plasma exchange therapy in two pediatric toxic epidermal necrolysis cases related to COVID ‐19
Author(s) -
Varol Fatih,
Can Yasar Yusuf,
Sahin Ebru,
Durak Cansu,
Kilic Aziz,
Sahin Ceyhan,
Gursoy Fatima,
Akin Tugba
Publication year - 2022
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.21997
Subject(s) - toxic epidermal necrolysis , medicine , mucocutaneous zone , hydroxychloroquine , dermatology , covid-19 , therapeutic plasma exchange , disease , immunology , pathology , surgery , infectious disease (medical specialty)
Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life‐threatening mucocutaneous reactions characterized by necrosis and detachment of the epidermis. Drugs and bacterial or viral infections are the most common causes of SJS/TEN. Although cases of SJS/TEN have been reported after hydroxychloroquine, vaccine (mRNA [Biontech], and inactivated vaccine [Sinovac]) administration and during the clinical course of active Coronavirus disease 2019 (COVID‐19), limited data is indicating the COVID‐19 disease as a triggering factor. Also, there are no pediatric cases of SJS/TEN associated with COVID‐19 in the literature. Herein we reported two pediatric cases with a diagnosis of TEN related to COVID‐19. Therapeutic plasma exchange therapy was applied to both of our patients. Although there are a few adult cases in the literature, our article is the first pediatric case report about patients diagnosed with TEN related to COVID‐19 and successfully treated with plasma exchange.