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No increase in anti‐A isohemagglutinin titer after SARS‐CoV ‐2 infection: A retrospective cohort analysis of group O apheresis platelet donors
Author(s) -
Wasiluk Tomasz,
Bujno Magdalena,
Rybinska Kamila,
Rogowska Anna,
Zebrowska Agnieszka,
BoczkowskaRadziwon Barbara,
Piszcz Jaroslaw,
Bolkun Lukasz,
Radziwon Piotr
Publication year - 2021
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.21942
Subject(s) - medicine , titer , apheresis , immunology , antibody , asymptomatic , abo blood group system , retrospective cohort study , antibody titer , population , virology , platelet , environmental health
The risk of a hemolytic reaction during the transfusion of ABO non‐identical PC is determined by the presence of natural anti‐A IgM antibodies, the titer of which may increase after infections. The aim of the study was to evaluate the titer of anti‐A isohemagglutinins in platelet concentrate (PC) obtained by apheresis from group O donors who experienced SARS‐CoV‐2 infection, and to compare the titer before and after infection. A retrospective single‐center analysis of 21 PC donors with a previous COVID‐19 history was performed. The results showed neither a statistically important increase in the anti‐A IgM antibody titers nor a significant correlation between the anti‐A IgM antibody level and anti‐SARS‐CoV‐2S1 antibody titer in the donors with an asymptomatic or mild COVID‐19. Further population‐based studies on anti‐A titers are necessary for a comprehensive assessment of this phenomenon.