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Description of parallel and sequential configurations for concurrent therapeutic plasma exchange and continuous kidney replacement therapy in adults
Author(s) -
Kaushik Manish,
Liew Zhong Hong,
Sewa DuuWen,
Phua Ghee Chee,
Cao Ling,
Krishnamoorthy Thinesh Lee,
Ng Shin Yi,
Lim Amy Ee Lin,
Ng Li Choo,
Koniman Riece,
Teo Su Hooi,
Tan Han Khim
Publication year - 2021
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.21854
Subject(s) - medicine , therapeutic plasma exchange , renal replacement therapy , plasmapheresis , extracorporeal , intensive care medicine , surgery , immunology , antibody
Therapeutic plasma exchange (TPE) and continuous kidney replacement therapy (CKRT) are extracorporeal therapeutic procedures often implemented in management of patients. Critically ill patients may be afflicted with disease processes that require both TPE and CKRT. Performing TPE discontinuous with CKRT is technically easier, however, it disrupts CKRT and may compromise with CKRT efficiency or hemofilter life. Concurrent TPE with CKRT offers several advantages including simultaneous control of disease process and correction of electrolyte, fluid, and acid‐base disturbances that may accompany TPE. Additionally, TPE may be performed by either centrifugation method or membrane plasma separation method. The technical specifications of these methods may influence the methodology of concurrent connections. This report describes and reviews two different approaches to circuit arrangements when establishing concurrent TPE and CKRT.